| First Author | Anastasiades PG | Year | 2016 |
| Journal | Nat Commun | Volume | 7 |
| Pages | 10584 | PubMed ID | 26843463 |
| Mgi Jnum | J:236276 | Mgi Id | MGI:5805614 |
| Doi | 10.1038/ncomms10584 | Citation | Anastasiades PG, et al. (2016) GABAergic interneurons form transient layer-specific circuits in early postnatal neocortex. Nat Commun 7:10584 |
| abstractText | GABAergic interneurons play key roles in cortical circuits, yet little is known about their early connectivity. Here we use glutamate uncaging and a novel optogenetic strategy to track changes in the afferent and efferent synaptic connections of developing neocortical interneuron subtypes. We find that Nkx2-1-derived interneurons possess functional synaptic connections before emerging pyramidal cell networks. Subsequent interneuron circuit maturation is both subtype and layer dependent. Glutamatergic input onto fast spiking (FS), but not somatostatin-positive, non-FS interneurons increases over development. Interneurons of both subtype located in layers (L) 4 and 5b engage in transient circuits that disappear after the somatosensory critical period. These include a pathway mediated by L5b somatostatin-positive interneurons that specifically targets L4 during the first postnatal week. The innervation patterns of immature cortical interneuron circuits are thus neither static nor progressively strengthened but follow a layer-specific choreography of transient connections that differ from those of the adult brain. |
