| First Author | Smid JR | Year | 2004 |
| Journal | J Dent Res | Volume | 83 |
| Issue | 1 | Pages | 35-9 |
| PubMed ID | 14691110 | Mgi Jnum | J:105275 |
| Mgi Id | MGI:3614602 | Doi | 10.1177/154405910408300107 |
| Citation | Smid JR, et al. (2004) Mouse cellular cementum is highly dependent on growth hormone status. J Dent Res 83(1):35-9 |
| abstractText | Cementum is known to be growth-hormone (GH)-responsive, but to what extent is unclear. This study examines the effects of extremes of GH status on cementogenesis in three lines of genetically modified mice; GH excess (giant), GH antagonist excess (dwarf), and GH receptor-deleted (GHR-KO) (dwarf). Age-matched mandibular molar tissues were processed for light microscope histology. Digital images of sections of first molar teeth were captured for morphometric analysis of lingual root cementum. Cross-sectional area of the cellular cementum was a sensitive guide to GH status, being reduced nearly 10-fold in GHR-KO mice, three-fold in GH antagonist mice, and increased almost two-fold in giant mice (p < 0.001). Cellular cementum length was similarly influenced by GH status, but to a lesser extent. Acellular cementum was generally unaffected. This study reveals cellular cementum to be a highly responsive GH target tissue, which may have therapeutic applications in assisting regeneration of the periodontium. |
