| First Author | Cavallaro S | Year | 1997 |
| Journal | Proc Natl Acad Sci U S A | Volume | 94 |
| Issue | 18 | Pages | 9669-73 |
| PubMed ID | 9275181 | Mgi Jnum | J:42821 |
| Mgi Id | MGI:1096309 | Doi | 10.1073/pnas.94.18.9669 |
| Citation | Cavallaro S, et al. (1997) Late memory-related genes in the hippocampus revealed by RNA fingerprinting. Proc Natl Acad Sci U S A 94(18):9669-73 |
| abstractText | Although long-term memory is thought to require a cellular program of gene expression and increased protein synthesis, the identity of proteins critical for associative memory is largely unknown. We used RNA fingerprinting to identify candidate memory-related genes (MRGs), which were up-regulated in the hippocampus of water maze-trained rats, a brain area that is critically involved in spatial learning. Two of the original 10 candidate genes implicated by RNA fingerprinting, the rat homolog of the ryanodine receptor type-2 and glutamate dehydrogenase (EC 1.4.1.3), were further investigated by Northern blot analysis, reverse transcription-PCR, and in situ hybridization and confirmed as MRGs with distinct temporal and regional expression. Successive RNA screening as illustrated here may help to reveal a spectrum of MRGs as they appear in distinct domains of memory storage. |
