| Primary Identifier | IPR030844 | Type | Family |
| Short Name | PAN3 |
| description | Pan3 is a regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of the two eukaryotic poly(A) nuclease complexes (Ccr4-Caf1 and Pan2-Pan3) involved in mRNA decay [, ]. It contains a PABP-interacting motif 2 (PAM2) that binds to the C-terminal domain of polyA binding proteins (PABPs) []. It recruits the Pan2-Pan3 complex to mRNA through the Pan3-PABP interaction [].Regulation of mRNA decay rates in eukaryotic cells affects gene expression []. The Pan2-Pan3 complex shortens cytoplasmic mRNA 3' polyA tails to regulate mRNA stability []. In the complex Pan2 provides the catalytic activity, whereas Pan3 mediates Pan2 recruitment to mRNA targets []. |
