| First Author | Taylor C | Year | 1998 |
| Journal | Cancer Detect Prev | Volume | 22 |
| Issue | 4 | Pages | 350-6 |
| PubMed ID | 9674878 | Mgi Jnum | J:50429 |
| Mgi Id | MGI:1303343 | Doi | 10.1046/j.1525-1500.1998.cdoa36.x |
| Citation | Taylor C, et al. (1998) c-Myc-associated genomic instability of the dihydrofolate reductase locus in vivo. Cancer Detect Prev 22(4):350-6 |
| abstractText | c-Myc overexpression is associated with the locus-specific amplification and rearrangement of the dihydrofolate reductase (DHFR) gene. This has been shown in lymphoid and nonlymphoid cell lines. Furthermore, c-Myc-dependent DHFR gene amplification occurs independent of species origins; it has been described in rat, hamster, mouse, and human cell lines. Here, we report on c-Myc-dependent amplification of the DHFR gene in vivo, using an animal model of c-Myc-dependent neoplasia, the mouse plasmacytoma. |
