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Publication : Mammalian Fat1 cadherin regulates actin dynamics and cell-cell contact.

First Author  Tanoue T Year  2004
Journal  J Cell Biol Volume  165
Issue  4 Pages  517-28
PubMed ID  15148305 Mgi Jnum  J:91137
Mgi Id  MGI:3046012 Doi  10.1083/jcb.200403006
Citation  Tanoue T, et al. (2004) Mammalian Fat1 cadherin regulates actin dynamics and cell-cell contact. J Cell Biol 165(4):517-28
abstractText  Fat cadherins form a distinct subfamily of the cadherin gene superfamily, and are featured by their unusually large extracellular domain. In this work, we investigated the function of a mammalian Fat cadherin. Fat1 was localized at filopodial tips, lamellipodial edges, and cell-cell boundaries, overlapping with dynamic actin structures. RNA interference-mediated knockdown of Fat1 resulted in disorganization of cell junction-associated F-actin and other actin fibers/cables, disturbance of cell-cell contacts, and also inhibition of cell polarity formation at wound margins. Furthermore, we identified Ena/vasodilator-stimulated phosphoproteins as a potential downstream effector of Fat1. These results suggest that Fat1 regulates actin cytoskeletal organization at cell peripheries, thereby modulating cell contacts and polarity.
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