| First Author | Sévigny G | Year | 1995 |
| Journal | Biochem Biophys Res Commun | Volume | 216 |
| Issue | 1 | Pages | 279-83 |
| PubMed ID | 7488101 | Mgi Jnum | J:29647 |
| Mgi Id | MGI:77172 | Doi | 10.1006/bbrc.1995.2621 |
| Citation | Sevigny G, et al. (1995) The cytosolic chaperonin subunit TRiC-P5 begins to be expressed at the two-cell stage in mouse embryos. Biochem Biophys Res Commun 216(1):279-83 |
| abstractText | The cytosolic chaperonin TRiC is a large protein complex involved in the folding of newly synthesized actin and tubulin. The fertilization of the mouse oocyte is followed by a remodelling of the actin and tubulin filaments. The TRiC subunit TCP1 is expressed only from the 4-cell stage on, even though actin and tubulin are synthesized in the previous stages. We investigated the onset of synthesis of another subunit, TRiC-P5, during early mouse embryogenesis. We report that TRiC-P5 is synthesized at the 2-cell stage in an alpha-amanitin sensitive manner. Thus, it is expressed before TCP1 and is one of the first proteins to be synthesized after zygotic genome activation. |
