| First Author | Boccasavia VL | Year | 2021 |
| Journal | Cell Rep | Volume | 34 |
| Issue | 11 | Pages | 108861 |
| PubMed ID | 33730591 | Mgi Jnum | J:304274 |
| Mgi Id | MGI:6694819 | Doi | 10.1016/j.celrep.2021.108861 |
| Citation | Boccasavia VL, et al. (2021) Antigen presentation between T cells drives Th17 polarization under conditions of limiting antigen. Cell Rep 34(11):108861 |
| abstractText | T cells form immunological synapses with professional antigen-presenting cells (APCs) resulting in T cell activation and the acquisition of peptide antigen-MHC (pMHC) complexes from the plasma membrane of the APC. They thus become APCs themselves. We investigate the functional outcome of T-T cell antigen presentation by CD4 T cells and find that the antigen-presenting T cells (Tpres) predominantly differentiate into regulatory T cells (Treg), whereas T cells that have been stimulated by Tpres cells predominantly differentiate into Th17 pro-inflammatory cells. Using mice deficient in pMHC uptake by T cells, we show that T-T antigen presentation is important for the development of experimental autoimmune encephalitis and Th17 cell differentiation in vivo. By varying the professional APC:T cell ratio, we can modulate Treg versus Th17 differentiation in vitro and in vivo, suggesting that T-T antigen presentation underlies proinflammatory responses in conditions of antigen scarcity. |
