| Type | MGI:General | Description | 25% incidence of spontaneous carcinoma development with myoepithelial and basaloid differentiation in salivary glands in mutants over 6 months of age, resembling human basal cell adenocarcinoma with myoepithelial differentiation tumors develop proximate to submandibular glands and to a lesser extent in the sublingual and parotid glands exhibit central cavitary lesions filled with necrotic debris that are lined by tumor cells and contain a mixture of spindle cells interspersed with epitheloid cells and lesser basaloid to clear cell differentiation tumors show variable presence of high mitotic rate, pleomorphism (anisokaryosis and anisocytosis), and invasion into adjacent salivary glands |
