| First Author | Konishi Y | Year | 2004 |
| Journal | Science | Volume | 303 |
| Issue | 5660 | Pages | 1026-30 |
| PubMed ID | 14716021 | Mgi Jnum | J:90373 |
| Mgi Id | MGI:3043433 | Doi | 10.1126/science.1093712 |
| Citation | Konishi Y, et al. (2004) Cdh1-APC controls axonal growth and patterning in the mammalian brain. Science 303(5660):1026-30 |
| abstractText | The anaphase-promoting complex (APC) is highly expressed in postmitotic neurons, but its function in the nervous system was previously unknown. We report that the inhibition of Cdh1-APC in primary neurons specifically enhanced axonal growth. Cdh1 knockdown in cerebellar slice overlay assays and in the developing rat cerebellum in vivo revealed cell-autonomous abnormalities in layer-specific growth of granule neuron axons and parallel fiber patterning. Cdh1 RNA interference in neurons was also found to override the inhibitory influence of myelin on axonal growth. Thus, Cdh1-APC appears to play a role in regulating axonal growth and patterning in the developing brain that may also limit the growth of injured axons in the adult brain. |
