| First Author | Surmacz E | Year | 1992 |
| Journal | Exp Cell Res | Volume | 199 |
| Issue | 2 | Pages | 275-8 |
| PubMed ID | 1371961 | Mgi Jnum | J:1810 |
| Mgi Id | MGI:50334 | Doi | 10.1016/0014-4827(92)90435-b |
| Citation | Surmacz E, et al. (1992) The role of the IGF1 receptor in the regulation of cdc2 mRNA levels in fibroblasts. Exp Cell Res 199(2):275-8 |
| abstractText | The levels of cdc2 mRNA increase when quiescent cells are stimulated by growth factors. In BALB/c 3T3, both platelet-derived growth factor and insulin-like growth factor 1 (IGF-1) are required to increase cdc2 mRNA levels. In p6 cells, which constitutively overexpress the IGF-1 receptor, IGF-1 is sufficient. The importance of the IGF-1/IGF-1 receptor interaction in regulating the levels of cdc2 mRNA was further confirmed by showing that an antisense oligodeoxynucleotide to the IGF-1 receptor RNA inhibited the IGF-1-mediated increase. |
