| First Author | Samardzic T | Year | 2002 |
| Journal | Eur J Immunol | Volume | 32 |
| Issue | 2 | Pages | 561-7 |
| PubMed ID | 11828373 | Mgi Jnum | J:74752 |
| Mgi Id | MGI:2159059 | Doi | 10.1002/1521-4141(200202)32:2<561::AID-IMMU561>3.0.CO;2-H |
| Citation | Samardzic T, et al. (2002) Reduction of marginal zone B cells in CD22-deficient mice. Eur J Immunol 32(2):561-7 |
| abstractText | CD22 is a B cell-specific member of the immunoglobulin superfamily and binds to sialic acid. CD22 inhibits B cell receptor signaling. Mice deficient for CD22 show a largely normal B cell development. Here, we have performed a detailed analysis of the splenic B cell population and found that the subset of marginal zone (MZ) B cells was selectively reduced in CD22-deficient mice. CD22-deficient mice showed a lack of TNP-ficoll capturing cells in the MZ and a reduced response to TNP-ficoll, particularly when the antigen was applied intravenously. CD22-deficient B cells showed both enhanced motility as well as enhanced chemotaxis to certain chemokines. The altered chemokine responsiveness or the higher signaling capacity of CD22-deficient B cells may lead to the compromised MZ B cell compartment, as both processes have previously been shown to affect MZ composition. |
