| Primary Identifier | MGI:2447353 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Dmtn |
| Transmission | Germline | Strain of Origin | 129S4/SvJaeSor |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Exons 11 through 15 were replaced with a neomycin selection cassette inserted by homologous recombination. The deleted sequence encoded the carboxy terminal headpiece domain of the endogenous protein. RT-PCR analysis of kidney and brain tissues indicated an absence of normal transcript in homozygous mutant mice. A single truncated peptide species, corresponding to the targeted deletion, was identified in homozygous mutant mice by Western blot analysis. |
