| First Author | Reshetnikova ES | Year | 2012 |
| Journal | Cell Immunol | Volume | 272 |
| Issue | 2 | Pages | 182-92 |
| PubMed ID | 22078318 | Mgi Jnum | J:181376 |
| Mgi Id | MGI:5311100 | Doi | 10.1016/j.cellimm.2011.10.013 |
| Citation | Reshetnikova ES, et al. (2012) Differential expression of FCRLA in naive and activated mouse B cells. Cell Immunol 272(2):182-92 |
| abstractText | FCRLA is an intracellular B cell protein that belongs to the FcR-like family. Using newly generated FCRLA-specific antibodies, we studied the constitutive expression pattern of mouse FCRLA and monitored changes during an immune response and following in vitro B cell activation. All B cell subpopulations examined expressed FCRLA. However, the level of FCRLA expression is determined by the stage of B cell differentiation. Low expression of FCRLA is characteristic of naive follicular and marginal zone B cells. High expression was detected in a small fraction of activated B cells scattered along migratory pathways in the lymphoid tissues. FCRLA-bright cells could be subdivided into two subpopulations, with high and low/undetectable level of intracellular immunoglobulins, which phenotypically resemble either plasma or memory B cells. High expression of FCRLA in subset(s) of terminally differentiated B-cells suggests that, being an ER protein, FCRLA may participate in the regulation of immunoglobulin assembly and secretion. |
