| First Author | Segaud J | Year | 2022 |
| Journal | Nat Commun | Volume | 13 |
| Issue | 1 | Pages | 4703 |
| PubMed ID | 36050303 | Mgi Jnum | J:344134 |
| Mgi Id | MGI:7334268 | Doi | 10.1038/s41467-022-32196-1 |
| Citation | Segaud J, et al. (2022) Context-dependent function of TSLP and IL-1beta in skin allergic sensitization and atopic march. Nat Commun 13(1):4703 |
| abstractText | Atopic diseases, including atopic dermatitis (AD) and asthma, affect a large proportion of the population, with increasing prevalence worldwide. AD often precedes the development of asthma, known as the atopic march. Allergen sensitization developed through the barrier-defective skin of AD has been recognized to be a critical step leading to asthma, in which thymic stromal lymphopoietin (TSLP) was previously shown to be critical. In this study, using a laser-assistant microporation system to disrupt targeted skin layers for generating micropores at a precise anatomic depth of mouse skin, we model allergen exposure superficially or deeply in the skin, leading to epicutaneous sensitization or dermacutaneous sensitization that is associated with a different cytokine microenvironment. Our work shows a differential requirement for TSLP in these two contexts, and identifies an important function for IL-1beta, which is independent of TSLP, in promoting allergen sensitization and subsequent allergic asthma. |
