| Primary Identifier | MGI:7611791 | Allele Type | Targeted |
| Attribute String | Hypomorph, Inserted expressed sequence | Gene | Gfi1 |
| Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Most of the coding sequence was replaced with the corresponding human sequence with a single nucleotide polymorphism of asparagine at position 36 (36N). This variant is associated with increased risk for acute myeloid leukemia in humans. A neomycin selection cassette from the targeting vector is retained and leads to an 80-90% reduction of normal GFI1 expression. |
