| First Author | Shen MM | Year | 2000 |
| Journal | Trends Genet | Volume | 16 |
| Issue | 7 | Pages | 303-9 |
| PubMed ID | 10858660 | Mgi Jnum | J:63090 |
| Mgi Id | MGI:1860415 | Doi | 10.1016/s0168-9525(00)02006-0 |
| Citation | Shen MM, et al. (2000) The EGF-CFC gene family in vertebrate development. Trends Genet 16(7):303-9 |
| abstractText | EGF-CFC genes encode extracellular proteins that play key roles in intercellular signaling pathways during vertebrate embryogenesis. Mutations in zebrafish and mouse EGF-CFC genes lead to defects in germ-layer formation, anterior-posterior axis orientation and left-right axis specification. In addition, members of the EGF-CFC family have been implicated in carcinogenesis. Although formerly regarded as signaling molecules that are distant relatives of epidermal growth factor (EGF), recent findings indicate that EGF-CFC proteins act as essential cofactors for Nodal, a member of the transforming growth factor beta (TGF-beta) family. Here, we review molecular genetic evidence from mouse and zebrafish on biological and biochemical roles of the EGF-CFC family, and discuss differing models for EGF-CFC protein function. |
