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Publication : Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation.

First Author  Uhlenhaut NH Year  2009
Journal  Cell Volume  139
Issue  6 Pages  1130-42
PubMed ID  20005806 Mgi Jnum  J:157008
Mgi Id  MGI:4429740 Doi  10.1016/j.cell.2009.11.021
Citation  Uhlenhaut NH, et al. (2009) Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation. Cell 139(6):1130-42
abstractText  In mammals, the transcription factor SRY, encoded by the Y chromosome, is normally responsible for triggering the indifferent gonads to develop as testes rather than ovaries. However, testis differentiation can occur in its absence. Here we demonstrate in the mouse that a single factor, the forkhead transcriptional regulator FOXL2, is required to prevent transdifferentiation of an adult ovary to a testis. Inducible deletion of Foxl2 in adult ovarian follicles leads to immediate upregulation of testis-specific genes including the critical SRY target gene Sox9. Concordantly, reprogramming of granulosa and theca cell lineages into Sertoli-like and Leydig-like cell lineages occurs with testosterone levels comparable to those of normal XY male littermates. Our results show that maintenance of the ovarian phenotype is an active process throughout life. They might also have important medical implications for the understanding and treatment of some disorders of sexual development in children and premature menopause in women.
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