Primary Identifier | MGI:1935129 | Organism | mouse, laboratory |
Chromosome | 8 | NCBI Gene Number | 93762 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and histone octamer slider activity. Predicted to contribute to histone binding activity. Involved in negative regulation of transcription by RNA polymerase I; positive regulation of DNA replication; and rDNA heterochromatin formation. Acts upstream of or within cellular response to leukemia inhibitory factor; chromatin remodeling; and positive regulation of DNA-templated transcription. Located in nucleus. Part of NoRC complex; chromatin silencing complex; and pericentric heterochromatin. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human SMARCA5 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5). PHENOTYPE: Homozygous mutant mice die during early embryonic development. [provided by MGI curators] |