| First Author | Li X | Year | 2000 |
| Journal | Nat Cell Biol | Volume | 2 |
| Issue | 5 | Pages | 302-9 |
| PubMed ID | 10806482 | Mgi Jnum | J:62052 |
| Mgi Id | MGI:1858279 | Doi | 10.1038/35010579 |
| Citation | Li X, et al. (2000) PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor [see comments]. Nat Cell Biol 2(5):302-9 |
| abstractText | Platelet-derived growth factors (PDGFs) are important in many types of mesenchymal cell. Here we identify a new PDGF, PDGF-C, which binds to and activates the PDGF alpha-receptor. PDGF-C is activated by proteolysis and induces proliferation of fibroblasts when overexpressed in transgenic mice. In situ hybridization analysis in the murine embryonic kidney shows preferential expression of PDGF-C messenger RNA in the metanephric mesenchyme during epithelial conversion. Analysis of kidneys lacking the PDGF alpha-receptor shows selective loss of mesenchymal cells adjacent to sites of expression of PDGF-C mRNA; this is not found in kidneys from animals lacking PDGF-A or both PDGF-A and PDGF-B, indicating that PDGF-C may have a unique function. |
