| First Author | Aase K | Year | 2002 |
| Journal | Mech Dev | Volume | 110 |
| Issue | 1-2 | Pages | 187-91 |
| PubMed ID | 11744381 | Mgi Jnum | J:73808 |
| Mgi Id | MGI:2156907 | Doi | 10.1016/s0925-4773(01)00560-3 |
| Citation | Aase K, et al. (2002) Expression analysis of PDGF-C in adult and developing mouse tissues. Mech Dev 110(1-2):187-91 |
| abstractText | There are four members of the platelet-derived growth factor (PDGF) family; PDGF-A, PDGF-B, PDGF-C and PDGF-D. Their biological effects are mediated via two tyrosine kinase receptors, PDGFR-alpha and PDGFR-beta, and PDGF-mediated signaling is critical for development of many organ systems. Analysis in adult tissues showed that PDGF-C was mainly expressed in kidney, testis, liver, heart and brain. During development, PDGF-C expression was widespread and dynamic, and found in somites and their derivatives, in kidney, lung, brain, and in several other tissues, particularly at sites of developing epidermal openings. PDGF-C may therefore have unique functions during tissue development and maintenance. |
