| First Author | Heng JK | Year | 1996 |
| Journal | J Virol | Volume | 70 |
| Issue | 7 | Pages | 4517-22 |
| PubMed ID | 8676477 | Mgi Jnum | J:34230 |
| Mgi Id | MGI:81696 | Doi | 10.1128/jvi.70.7.4517-4522.1996 |
| Citation | Heng JK, et al. (1996) Alpha/beta interferons increase host resistance to murine AIDS. J Virol 70(7):4517-22 |
| abstractText | Murine AIDS (MAIDS) is caused by a defective retrovirus present in the LP-BM5 murine leukemia virus mixture. Strains of inbred mice differ in resistance to MAIDS development; some are susceptible (e.g., C57BL/6), while others are resistant (e.g., CBA and B10.BR). As an early block to viral replication in resistant mice has been demonstrated previously by PCR studies, we postulated that alpha/beta interferons (IFN-alpha/beta) may be involved in resistance to MAIDS. Susceptible C57BL/6 mice infected with LP-BM5 were treated with IFN-alpha/beta or Newcastle disease virus. Newcastle disease virus induces high endogenous IFN-alpha/beta production in mice. Both treatments delayed the development of MAIDS, as assessed by splenomegaly and T- and B-cell proliferation. In addition, an IFN-alpha/beta response was detected by reverse transcription-PCR and dot blotting 3, 6, and 9 h after LP-BM5 infection in resistant mice but not in susceptible mice. These results suggest that the ability to produce IFN-alpha/beta in response to LP-BM5 infection may contribute to host resistance to MAIDS. |
