| First Author | Gao P | Year | 2020 |
| Journal | Biochem Biophys Res Commun | Volume | 526 |
| Issue | 1 | Pages | 199-205 |
| PubMed ID | 32201077 | Mgi Jnum | J:293189 |
| Mgi Id | MGI:6447204 | Doi | 10.1016/j.bbrc.2020.03.069 |
| Citation | Gao P, et al. (2020) CSK promotes innate immune response to DNA virus by phosphorylating MITA. Biochem Biophys Res Commun 526(1):199-205 |
| abstractText | Upon detection of viral DNA, the cytoplasmic DNA sensor cyclic GMP-AMP (cGAMP) synthase (cGAS) utilizes GTP and ATP as substrates to synthesize the second messenger molecule 2'3'cyclic GMP-AMP (cGAMP), which binds to the ER-associated adaptor protein MITA/STING to signal innate antiviral response to DNA virus. How the cGAS-MITA pathways are post-translationally regulated is not fully understood. In this study, we identified the tyrosine kinase CSK as a positive regulator of cGAS-MITA mediated innate antiviral response. CSK-deficiency inhibits DNA virus-triggered induction of downstream antiviral effector genes. Following DNA virus infection, CSK phosphorylates MITA at Y240 and Y245, which is important for its activation. These results suggest that CSK plays a role in modulating innate immune response to DNA virus. |
