| First Author | Kolle G | Year | 2000 |
| Journal | Mech Dev | Volume | 90 |
| Issue | 2 | Pages | 181-93 |
| PubMed ID | 10642437 | Mgi Jnum | J:60432 |
| Mgi Id | MGI:1353278 | Doi | 10.1016/s0925-4773(99)00248-8 |
| Citation | Kolle G, et al. (2000) CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis. Mech Dev 90(2):181-93 |
| abstractText | Development of the vertebrate central nervous system is thought to be controlled by intricate cell-cell interactions and spatio-temporally regulated gene expressions. The details of these processes are still not fully understood. We have isolated a novel vertebrate gene, CRIM1/Crim1, in human and mouse. Human CRIM1 maps to chromosome 2p21 close to the Spastic Paraplegia 4 locus. Crim1 is expressed in the notochord, somites, floor plate, early motor neurons and interneuron subpopulations within the developing spinal cord. CRIM1 appears to be evolutionarily conserved and encodes a putative transmembrane protein containing an IGF-binding protein motif and multiple cysteine-rich repeats similar to those in the BMP-associating chordin and sog proteins. Our results suggest a role for CRIM1/Crim1 in CNS development possibly via growth factor binding. |
