| First Author | Georgas K | Year | 2000 |
| Journal | Dev Dyn | Volume | 219 |
| Issue | 4 | Pages | 582-7 |
| PubMed ID | 11084657 | Mgi Jnum | J:65872 |
| Mgi Id | MGI:1927403 | Doi | 10.1002/1097-0177(2000)9999:9999<::AID-DVDY1072>3.0.CO;2-I |
| Citation | Georgas K, et al. (2000) Characterisation of crim1 expression in the developing mouse urogenital tract reveals a sexually dimorphic gonadal expression pattern. Dev Dyn 219(4):582-7 |
| abstractText | The Crim1 gene encodes a putative transmembrane protein with an IGF-binding protein motif and multiple chordin-like cysteine-rich repeats. In chordin, such repeats are responsible for its dorsalising activity and for binding to bone morphogenic proteins (BMPs). Crim1 displays a dynamic expression pattern in a variety of developing organs, including the CNS and the lens. We have undertaken a detailed expression pattern analysis of Crim1 in the developing mouse urogenital system. During metanephric development, Crim1 showed expression both in the ureteric tree, the early condensing mesenchyme and distal comma-shaped bodies. As the nephron elongates, Crim1 becomes expressed in the proximal end of the S-shaped bodies. Crim1 also displays a striking male-specific expression pattern in the fetal gonads, its expression strongest in the Sertoli cells of the developing testis. Copyright 2000 Wiley-Liss, Inc. |
