| Primary Identifier | MGI:5003488 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(Prnp/IGHG1)588Aag |
| Strain of Origin | B6;129S7-Prnp<tm1Cwe> | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | The transgene encodes a soluble, dimerizing fusion protein comprising the normal mouse prion protein, without the carboxyl terminal GPI attachment signal, joined to the Fc region of the human immunoglobulin heavy chain gamma 1 constant region (Fcgamma). The construct includes ~6 kb of 5' flanking sequence, exon 1, intron 1 and a fused exon 2/3 from the mouse prion protein gene (Prnp). The Fcgamma coding sequence is modified to eliminate the binding sites for the Fcgamma receptor and complement. A loxP-flanked translation termination (STOP) cassette has been inserted upstream of the open reading frame, blocking expression of the fusion protein until the cassette is excised by Cre recombinase. |
