Primary Identifier | MGI:1333849 | Organism | mouse, laboratory |
Chromosome | 19 | NCBI Gene Number | 19395 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction and cellular response to calcium ion. Predicted to be located in cytosol. Predicted to be active in plasma membrane. Is expressed in brain; embryo; and telencephalon. Used to study leukocyte adhesion deficiency 3. Human ortholog(s) of this gene implicated in platelet-type bleeding disorder 18. Orthologous to human RASGRP2 (RAS guanyl releasing protein 2). PHENOTYPE: Mice homozygous for a knock-out allele do not undergo spontaneous hemorrhaging but exhibit impaired platelet aggregation, resistance to collagen-induced thrombosis, and increased bleeding times after tail transection. [provided by MGI curators] |