| First Author | Miniou P | Year | 1999 |
| Journal | Nucleic Acids Res | Volume | 27 |
| Issue | 19 | Pages | e27 |
| PubMed ID | 10481039 | Mgi Jnum | J:67906 |
| Mgi Id | MGI:1931679 | Doi | 10.1093/nar/27.19.e27 |
| Citation | Miniou P, et al. (1999) Gene targeting restricted to mouse striated muscle lineage. Nucleic Acids Res 27(19):e27 |
| abstractText | Spatially and temporally regulated somatic mutations can be achieved by using the Cre/LoxP recombination system of bacteriophage P1. In order to develop gene knockouts restricted to striated muscle, we generated a transgenic mouse line expressing Cre recombinase under the control of the human alpha-skeletal actin promoter. Specific excision of a loxP-flanked gene was demonstrated in striated muscle, heart and skeletal muscle, in a pattern very similar to the expression of the endogenous alpha-skeletal actin gene. Therefore, the reported transgenic line can be used to target inactivation or activation of a given gene to the skeletal muscle lineage. |
