Other
25 Authors
- Kusminski CM,
- Deng H,
- Williams KW,
- Liu T,
- Gordillo R,
- Kim M,
- Li N,
- Childs GV,
- Schultz RD,
- Sun K,
- Zhao S,
- Caron A,
- Zhu Q,
- Elmquist JK,
- Zhang Z,
- Odle AK,
- Deng Y,
- Scherer PE,
- He Z,
- Sun J,
- An Z,
- Xiong W,
- Lee CE,
- Zhu Y,
- Zhang N
| First Author | Zhao S | Year | 2019 |
| Journal | Cell Metab | Volume | 30 |
| Issue | 4 | Pages | 706-719.e6 |
| PubMed ID | 31495688 | Mgi Jnum | J:283680 |
| Mgi Id | MGI:6376763 | Doi | 10.1016/j.cmet.2019.08.005 |
| Citation | Zhao S, et al. (2019) Partial Leptin Reduction as an Insulin Sensitization and Weight Loss Strategy. Cell Metab 30(4):706-719.e6 |
| abstractText | The physiological role of leptin is thought to be a driving force to reduce food intake and increase energy expenditure. However, leptin therapies in the clinic have failed to effectively treat obesity, predominantly due to a phenomenon referred to as leptin resistance. The mechanisms linking obesity and the associated leptin resistance remain largely unclear. With various mouse models and a leptin neutralizing antibody, we demonstrated that hyperleptinemia is a driving force for metabolic disorders. A partial reduction of plasma leptin levels in the context of obesity restores hypothalamic leptin sensitivity and effectively reduces weight gain and enhances insulin sensitivity. These results highlight that a partial reduction in plasma leptin levels leads to improved leptin sensitivity, while pointing to a new avenue for therapeutic interventions in the treatment of obesity and its associated comorbidities. |
