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Protein Coding Gene : Arhgef5 Rho guanine nucleotide exchange factor 5
Primary Identifier  MGI:1858952 Organism  mouse, laboratory
Chromosome  6 NCBI Gene Number  54324
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable guanyl-nucleotide exchange factor activity. Acts upstream of or within several processes, including hematopoietic stem cell homeostasis; myeloid dendritic cell chemotaxis; and positive regulation of podosome assembly. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in cytoplasm and nucleus. Is expressed in cerebral cortex. Orthologous to human ARHGEF5 (Rho guanine nucleotide exchange factor 5).
PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased Th2 response in an ovalbumin-induced asthma model. [provided by MGI curators]
  • synonyms:
  • expressed sequence AW495314,
  • Rho guanine nucleotide exchange factor 5,
  • AA717842,
  • MGI:2141687,
  • AW495314,
  • EST AA717842,
  • RIKEN cDNA 2210412D05 gene,
  • 2210412D05Rik,
  • Arhgef5,
  • MGI:1919632
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Trail: ProteinCodingGene

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