| Primary Identifier | MGI:5570119 | Allele Type | Transgenic |
| Attribute String | Inducible, Recombinase | Gene | Tg(Aire-cre/Esr1)1Mmat |
| Strain of Origin | C57BL/6 | Induced With | tamoxifen |
| Is Recombinase | true | Is Wild Type | false |
| molecularNote | A targeting vector was constructed from a BAC (RP23-461E7) containing the entire Aire gene by replacing the Aire start codon with the open reading frame of a cre/Esr1 (originally reported as ERT2) fusion sequence and the polyA signal of rabbit beta-globin. The linearized BAC construct was microinjected into C57BL/6 fertilized pronuclei and founders were identified by Southern blot analysis. One line was established and crossed to reporter mouse lines for further analyses. |
