| First Author | Okkenhaug K | Year | 2002 |
| Journal | Science | Volume | 297 |
| Issue | 5583 | Pages | 1031-4 |
| PubMed ID | 12130661 | Mgi Jnum | J:78412 |
| Mgi Id | MGI:2384372 | Doi | 10.1126/science.1073560 |
| Citation | Okkenhaug K, et al. (2002) Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice. Science 297(5583):1031-4 |
| abstractText | Class IA phosphoinositide 3-kinases (PI3Ks) are a family of p85/p110 heterodimeric lipid kinases that generate second messenger signals downstream of tyrosine kinases, thereby controlling cell metabolism, growth, proliferation, differentiation, motility, and survival. Mammals express three class IA catalytic subunits: p110alpha, p110beta, and p110delta. It is unclear to what extent these p110 isoforms have overlapping or distinct biological roles. Mice expressing a catalytically inactive form of p110delta (p110delta(D910A)) were generated by gene targeting. Antigen receptor signaling in B and T cells was impaired and immune responses in vivo were attenuated in p110delta mutant mice. They also developed inflammatory bowel disease. These results reveal a selective role for p110delta in immunity. |
