Primary Identifier | MGI:2443582 | Organism | mouse, laboratory |
Chromosome | 16 | NCBI Gene Number | 268860 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable 4-aminobutyrate:2-oxoglutarate transaminase activity; identical protein binding activity; and pyridoxal phosphate binding activity. Involved in behavioral response to cocaine. Located in mitochondrion. Is expressed in several structures, including ganglia; genitourinary system; hemolymphoid system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease; GABA aminotransferase deficiency; and Huntington's disease. Orthologous to human ABAT (4-aminobutyrate aminotransferase). PHENOTYPE: Mice with loss of expression in T cells show T cell differentiation abnormalities in vitro and decreased susceptibility to experimental autoimmune encephalomyelitis. [provided by MGI curators] |