| Primary Identifier | MGI:102949 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 15218 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in several processes, including lymphoid lineage cell migration into thymus; regulation of positive thymic T cell selection; and thymus epithelium morphogenesis. Acts upstream of or within several processes, including nail development; regulation of T cell differentiation in thymus; and thymus development. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; foregut; integumental system; male reproductive gland or organ; and thymus. Used to study DiGeorge syndrome and T-cell immunodeficiency, congenital alopecia, and nail dystrophy. Human ortholog(s) of this gene implicated in T-cell immunodeficiency, congenital alopecia, and nail dystrophy; alopecia; nail disease; and primary immunodeficiency disease. Orthologous to human FOXN1 (forkhead box N1). PHENOTYPE: Homozygotes for different mutations have in genetically determined absence or loss of hair and failed hair keratinization, premature lethality (differing by genetic background) and absence of thymus, resulting in multiple immune abnormalities. Heterozygotes have enlarged thymi. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
