| First Author | Bégay V | Year | 2018 |
| Journal | Sci Rep | Volume | 8 |
| Issue | 1 | Pages | 8417 |
| PubMed ID | 29849099 | Mgi Jnum | J:262554 |
| Mgi Id | MGI:6163042 | Doi | 10.1038/s41598-018-26579-y |
| Citation | Begay V, et al. (2018) The C/EBPbeta LIP isoform rescues loss of C/EBPbeta function in the mouse. Sci Rep 8(1):8417 |
| abstractText | The transcription factor C/EBPbeta regulates hematopoiesis, bone, liver, fat, and skin homeostasis, and female reproduction. C/EBPbeta protein expression from its single transcript occurs by alternative in-frame translation initiation at consecutive start sites to generate three isoforms, two long (LAP*, LAP) and one truncated (LIP), with the same C-terminal bZip dimerization domain. The long C/EBPbeta isoforms are considered gene activators, whereas the LIP isoform reportedly acts as a dominant-negative repressor. Here, we tested the putative repressor functions of the C/EBPbeta LIP isoform in mice by comparing monoallelic WT or LIP knockin mice with Cebpb knockout mice, in combination with monoallelic Cebpa mice. The C/EBPbeta LIP isoform was sufficient to function in coordination with C/EBPalpha in murine development, adipose tissue and sebocyte differentiation, and female fertility. Thus, the C/EBPbeta LIP isoform likely has more physiological functions than its currently known role as a dominant-negative inhibitor, which are more complex than anticipated. |
