| First Author | Carotta S | Year | 2014 |
| Journal | J Exp Med | Volume | 211 |
| Issue | 11 | Pages | 2169-81 |
| PubMed ID | 25288399 | Mgi Jnum | J:218674 |
| Mgi Id | MGI:5618184 | Doi | 10.1084/jem.20140425 |
| Citation | Carotta S, et al. (2014) The transcription factors IRF8 and PU.1 negatively regulate plasma cell differentiation. J Exp Med 211(11):2169-81 |
| abstractText | Activated B cells undergo immunoglobulin class-switch recombination (CSR) and differentiate into antibody-secreting plasma cells. The distinct transcriptomes of B cells and plasma cells are maintained by the antagonistic influences of two groups of transcription factors: those that maintain the B cell program, including BCL6 and PAX5, and plasma cell-promoting factors, such as IRF4 and BLIMP-1. We show that the complex of IRF8 and PU.1 controls the propensity of B cells to undergo CSR and plasma cell differentiation by concurrently promoting the expression of BCL6 and PAX5 and repressing AID and BLIMP-1. As the PU.1-IRF8 complex functions in a reciprocal manner to IRF4, we propose that concentration-dependent competition between these factors controls B cell terminal differentiation. |
