| First Author | Korhonen L | Year | 2005 |
| Journal | Mol Cell Neurosci | Volume | 28 |
| Issue | 1 | Pages | 85-95 |
| PubMed ID | 15607944 | Mgi Jnum | J:97752 |
| Mgi Id | MGI:3576204 | Doi | 10.1016/j.mcn.2004.08.015 |
| Citation | Korhonen L, et al. (2005) Hippocalcin protects against caspase-12-induced and age-dependent neuronal degeneration. Mol Cell Neurosci 28(1):85-95 |
| abstractText | Hippocalcin is a neuronal calcium binding protein, but its physiological function in brain is unknown. We show here that hippocampal neurons from hippocalcin-deficient mice are more vulnerable to degeneration, particularly using thapsigargin, elevating intracellular calcium. Caspase-12 was activated in neurons lacking hippocalcin, while calpain was unchanged. Neuronal viability was accompanied by endoplasmic reticulum (ER) stress and a change in the relative induction of the ER chaperone, BiP/GRP78. Neuronal apoptosis inhibitor protein (NAIP), known to interact with hippocalcin, was not altered, but hippocampal neurons from gene-deleted mice were more sensitive to excitotoxicity caused by kainic acid. In addition, an age-dependent increase in neurodegeneration occurred in the gene-deleted mice, showing that hippocalcin contributes to neuronal viability during aging. |
