Primary Identifier | MGI:5509194 | Allele Type | Targeted |
Gene | Pten | Transmission | Germline |
Strain of Origin | CD-1 | Is Recombinase | false |
Is Wild Type | false |
molecularNote | Five missense mutations were introduced into the nuclear localization sequences 3 and 4 in exon 7 and a neo selection cassette was inserted in intron 7 via homologous recombination. The expressed protein is localized predominantly in the cytoplasm. |