| Primary Identifier | IPR042277 | Type | Homologous_superfamily |
| Short Name | IST1-like |
| description | The endosomal sorting complex required for transport (ESCRT) machinery functions in several important eukaryotic cellular processes such as MVB (multivesicular body) formation. The AAA-ATPase Vps4 catalyzes disassembly of the ESCRT-III complex and may regulate membrane deformation and vesicle scission as well. Ist1 acts as a negative regulator of the MVB pathway by binding to the N-terminal MIT (microtubule interacting and transport) domain of Vps4 through its C-terminal region, with its 15 amino acids bearing strong homology to a conserved sequence motif called MIM1 (MIT interacting motif 1 []). This MIT domain is found in various proteins and enzymes including ubiquitin hydrolases proteases, ATPases (Spastin and VPS4 proteins) and ATPase activators (Vta1p/LIP5) []. |
