| First Author | Mattson MP | Year | 2006 |
| Journal | Cell Death Differ | Volume | 13 |
| Issue | 5 | Pages | 852-60 |
| PubMed ID | 16397579 | Mgi Jnum | J:126296 |
| Mgi Id | MGI:3760959 | Doi | 10.1038/sj.cdd.4401837 |
| Citation | Mattson MP, et al. (2006) Roles for NF-kappaB in nerve cell survival, plasticity, and disease. Cell Death Differ 13(5):852-60 |
| abstractText | Here we review evidence of roles for NF-kappaB in the regulation of developmental and synaptic plasticity, and cell survival in physiological and pathological settings. Signaling pathways modulating NF-kappaB activity include those engaged by neurotrophic factors, neurotransmitters, electrical activity, cytokines, and oxidative stress. Emerging findings support a pivotal role for NF-kappaB as a mediator of transcription-dependent enduring changes in the structure and function of neuronal circuits. Distinct subunits of NF-kappaB may uniquely affect cognition and behavior by regulating specific target genes. NF-kappaB activation can prevent the death of neurons by inducing the production of antiapoptotic proteins such as Bcl-2, IAPs and manganese superoxide dismutase (Mn-SOD). Recent findings indicate that NF-kappaB plays important roles in disorders such as epilepsy, stroke, Alzheimer's and Parkinson's diseases, as well as oncogenesis. Molecular pathways upstream and downstream of NF-kappaB in neurons are being elucidated and may provide novel targets for therapeutic intervention in various neurological disorders. |
