| First Author | Ji JW | Year | 2006 |
| Journal | Biochem Biophys Res Commun | Volume | 346 |
| Issue | 4 | Pages | 1254-60 |
| PubMed ID | 16793010 | Mgi Jnum | J:110504 |
| Mgi Id | MGI:3640426 | Doi | 10.1016/j.bbrc.2006.06.029 |
| Citation | Ji JW, et al. (2006) Analysis of cag-8: a novel poly(Q)-encoding gene in the mouse brain. Biochem Biophys Res Commun 346(4):1254-60 |
| abstractText | We identified 13 transcript isoforms of a trinucleotide-repeat-containing gene, cag-8, that is expressed almost exclusively in the mouse brain. The polypeptide deduced from the cDNA consists of 137 AAs, of which 74 are glutamines. The 130-kb gene is composed of 16 exons, from which at least 13 isoforms with variable UTRs are formed by alternative splicing. A strong positive cis-acting element was found in the neuroblastomaxglioma hybrid NG108-15 and human embryonic kidney HEK293 cell lines. The cag-8 protein was localized in the cytosol and in granular bodies within the nucleus. These findings indicate that cag-8 is a novel poly(Q)-encoding gene, the expression of which is confined primarily to the brain. |
