| First Author | Schuhmann B | Year | 2005 |
| Journal | J Neuroimmunol | Volume | 163 |
| Issue | 1-2 | Pages | 15-23 |
| PubMed ID | 15885304 | Mgi Jnum | J:101880 |
| Mgi Id | MGI:3605606 | Doi | 10.1016/j.jneuroim.2005.01.023 |
| Citation | Schuhmann B, et al. (2005) A role for brain-derived neurotrophic factor in B cell development. J Neuroimmunol 163(1-2):15-23 |
| abstractText | In the present study, we demonstrated a significant reduction of B lymphocytes in the blood, spleen and bone marrow of BDNF deficient mice. The observed developmental block in bone marrow B cell development was linked specifically to the Pre-BII stage. B lymphocytes express the BDNF receptors p75NTR and TrkB(gp95), while no BDNF expression was found. However, a strong BDNF expression was demonstrated in bone marrow stromal cells. An increase of intracellular free calcium [Ca2+]i in B lymphocytes after BDNF application confirms a direct responsiveness of B lymphocytes to BDNF. In conclusion, these results suggest a role of BDNF for normal B lymphocyte development through paracrine effects in the bone marrow. |
