| First Author | Fahl SP | Year | 2021 |
| Journal | Cell Rep | Volume | 34 |
| Issue | 5 | Pages | 108716 |
| PubMed ID | 33535043 | Mgi Jnum | J:304284 |
| Mgi Id | MGI:6694808 | Doi | 10.1016/j.celrep.2021.108716 |
| Citation | Fahl SP, et al. (2021) The E protein-TCF1 axis controls gammadelta T cell development and effector fate. Cell Rep 34(5):108716 |
| abstractText | TCF1 plays a critical role in T lineage commitment and the development of alphabeta lineage T cells, but its role in gammadelta T cell development remains poorly understood. Here, we reveal a regulatory axis where T cell receptor (TCR) signaling controls TCF1 expression through an E-protein-bound regulatory element in the Tcf7 locus, and this axis regulates both gammadelta T lineage commitment and effector fate. Indeed, the level of TCF1 expression plays an important role in setting the threshold for gammadelta T lineage commitment and modulates the ability of TCR signaling to influence effector fate adoption by gammadelta T lineage progenitors. This finding provides mechanistic insight into how TCR-mediated repression of E proteins promotes the development of gammadelta T cells and their adoption of the interleukin (IL)-17-producing effector fate. IL-17-producing gammadelta T cells have been implicated in cancer progression and in the pathogenesis of psoriasis and multiple sclerosis. |
