| First Author | Yoshida H | Year | 2005 |
| Journal | Nat Immunol | Volume | 6 |
| Issue | 1 | Pages | 49-56 |
| PubMed ID | 15568025 | Mgi Jnum | J:94874 |
| Mgi Id | MGI:3521632 | Doi | 10.1038/ni1146 |
| Citation | Yoshida H, et al. (2005) Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA. Nat Immunol 6(1):49-56 |
| abstractText | The livers of DNase II-deficient mouse embryos contain many macrophages carrying undigested DNA, and the embryos die in utero. Here we report that erythroid precursor cells underwent apoptosis in the livers of DNase II-deficient embryos and that in the liver, interferon-beta mRNA was expressed by the resident macrophages. When the DNase II-deficient mice were crossed with mice deficient in type I interferon receptor, the resultant 'double-mutant' mice were born healthy. The double-mutant embryos expressed interferon-beta mRNA, but the expression of a subset of the interferon-responsive genes dysregulated in DNase II-deficient embryos was restored to normal. These results indicate that the inability to degrade DNA derived from erythroid precursors results in interferon-beta production that induces expression of a specific set of interferon-responsive genes associated with embryonic lethality in DNase II-deficient mice. |
