| First Author | Lehman AL | Year | 1998 |
| Journal | Proc Natl Acad Sci U S A | Volume | 95 |
| Issue | 16 | Pages | 9436-41 |
| PubMed ID | 9689098 | Mgi Jnum | J:49046 |
| Mgi Id | MGI:1276616 | Doi | 10.1073/pnas.95.16.9436 |
| Citation | Lehman AL, et al. (1998) A very large protein with diverse functional motifs is deficient in rjs (runty, jerky, sterile) mice. Proc Natl Acad Sci U S A 95(16):9436-41 |
| abstractText | Three radiation-induced alleles of the mouse p locus, p(6H), p(25H), and p(bs), cause defects in growth, coordination, fertility, and maternal behavior in addition to p gene-related hypopigmentation. These alleles are associated with disruption of the p gene plus an adjacent gene involved hn the disorders listed. We have identified this adjacent gene, previously named rjs (runty jerky sterile), by positional cloning. The rjs cDNA is very large, covering 15,264 nucleotides. The predicted rjs- encoded protein (4,836 amino acids) contains several sequence motifs, including three RCC1 repeats, a structural motif in common with cytochrome b(5), and a HECT domain in common with Eg-BP ubiquitin ligase, Ore the basis of sequence homolog and conserved synteny; the rjs gene is the single mouse homolog of a previously described five- or six-member human gene family. This family is represented by at least two genes, HSC7541 and KIAA0393, from human chromosome 15q11-q13. HSC7541 and KIAA0393 lie close to, or within, st region commonly deleted in most Prader-Willi syndrome patients. Previous work has suggested that the multiple phenotypes in rjs mice might be due to a common neuroendacrine defect, In addition to this proposed mode of action, alternative functions of the rjs gene are evaluated in light of its known protein homologies. |
