| First Author | Parker NF | Year | 2016 |
| Journal | Nat Neurosci | Volume | 19 |
| Issue | 6 | Pages | 845-54 |
| PubMed ID | 27110917 | Mgi Jnum | J:279708 |
| Mgi Id | MGI:6210154 | Doi | 10.1038/nn.4287 |
| Citation | Parker NF, et al. (2016) Reward and choice encoding in terminals of midbrain dopamine neurons depends on striatal target. Nat Neurosci 19(6):845-54 |
| abstractText | Dopaminergic (DA) neurons in the midbrain provide rich topographic innervation of the striatum and are central to learning and to generating actions. Despite the importance of this DA innervation, it remains unclear whether and how DA neurons are specialized on the basis of the location of their striatal target. Thus, we sought to compare the function of subpopulations of DA neurons that target distinct striatal subregions in the context of an instrumental reversal learning task. We identified key differences in the encoding of reward and choice in dopamine terminals in dorsal versus ventral striatum: DA terminals in ventral striatum responded more strongly to reward consumption and reward-predicting cues, whereas DA terminals in dorsomedial striatum responded more strongly to contralateral choices. In both cases the terminals encoded a reward prediction error. Our results suggest that the DA modulation of the striatum is spatially organized to support the specialized function of the targeted subregion. |
