| First Author | Berrios J | Year | 2016 |
| Journal | Nat Commun | Volume | 7 |
| Pages | 10702 | PubMed ID | 26869263 |
| Mgi Jnum | J:235694 | Mgi Id | MGI:5800386 |
| Doi | 10.1038/ncomms10702 | Citation | Berrios J, et al. (2016) Loss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation. Nat Commun 7:10702 |
| abstractText | Motivated reward-seeking behaviours are governed by dopaminergic ventral tegmental area projections to the nucleus accumbens. In addition to dopamine, these mesoaccumbal terminals co-release other neurotransmitters including glutamate and GABA, whose roles in regulating motivated behaviours are currently being investigated. Here we demonstrate that loss of the E3-ubiquitin ligase, UBE3A, from tyrosine hydroxylase-expressing neurons impairs mesoaccumbal, non-canonical GABA co-release and enhances reward-seeking behaviour measured by optical self-stimulation. |
