| First Author | Luo X | Year | 1995 |
| Journal | Endocr Res | Volume | 21 |
| Issue | 1-2 | Pages | 517-24 |
| PubMed ID | 7588417 | Mgi Jnum | J:31106 |
| Mgi Id | MGI:78577 | Doi | 10.3109/07435809509030469 |
| Citation | Luo X, et al. (1995) A cell-specific nuclear receptor plays essential roles in adrenal and gonadal development. Endocr Res 21(1-2):517-24 |
| abstractText | Recent analyses of the cytochrome P450 steroid hydroxylases have established a key role for an orphan nuclear receptor, designated steroidogenic factor 1 (SF-1), in their coordinate, cell-selective expression. SF-1 was proposed to regulate the steroid hydroxylases by interacting with shared promoter elements in their 5'-flanking regions. During mouse embryonic development, SF-1 was expressed from the earliest stages of organogenesis of the steroidogenic tissues, suggesting a key role in steroidogenic cell differentiation. Finally, disruption of the gene encoding SF-1 revealed its essential function in the development of the adrenal glands and gonads and in pituitary gonadotrope function. These studies suggest that SF-1 acts at multiple levels of the reproductive axis to maintain reproductive competence. |
