| Primary Identifier | MGI:1857959 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Hoxd3 |
| Transmission | Germline | Strain of Origin | 129S7/SvEvBrd |
| Is Recombinase | false | Is Wild Type | false |
| description | Homozygous mutant mice have anterior homeotic transformations of cervical vertebrae I and II, the atlas and axis vertebrae. The atlas is fused with the skull, while the axis is altered to an "atlas-like" conformation (J:15678). Although null mutations of Hoxd3 and its paralog, Hoxa3, cause no defects in common, they interact in double mutant mice, the atlas being completely deleted (J:19447). |
| molecularNote | A neomycin cassette was inserted into sequences encoding the second helix of the homeobox domain. |
