| Primary Identifier | IPR037961 | Type | Domain |
| Short Name | SH3PXD2_PX |
| description | This entry represents the PX domain of SH3PXD2A and SH3PXD2B. The PX domain is involved in targeting of proteins to phosphoinositide-enriched membranes, and may also be involved in protein-protein interaction [].SH3PXD2A, also known as Fish or Tks5, is a scaffold protein with five SH3 domains and one PX domain. It is required for podosome formation, for degradation of the extracellular matrix, and for invasion of some cancer cells [, ]. SH3PXD2A binding partners include ADAM-family metalloproteases []and Nck adaptor proteins [].SH3 and PX domain-containing protein 2B (SH3PXD2B, also known as Fad49 or Tks4) is an adaptor protein required for functional podosome formation []. It binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides []. It regulates epidermal growth factor-dependent cell migration []and has been linked to cancer []. Mutations in the SH3PXD2B gene cause Frank-ter Haar syndrome, a rare disease characterised by abnormalities that affect bone, heart, and eye development []. It contains an N-terminal Phox homology (PX) domain and four SH3 domains. |
